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Monoclonal and Polyclonal Antibody Analysis assesses the strength of immune response, drug effect or disease pathology by detecting single specificity or multiple complexity of antibodies. Derived from one B-cell clone type monoclonal antibodies demonstrate precise attachment to distinct antigenic epitopes while polyclonal antibodies emerge from various B-cell lineages and display a diverse immune response profile. Understanding unique features of these antibodies generates essential information necessary for pharmaceutical creation and diagnostic reagent enhancement.